Versatile Type III Effector Mechanisms Can Disrupt Target-Cell Functions
نویسندگان
چکیده
منابع مشابه
Inflammasome Complexes: Emerging Mechanisms and Effector Functions
Canonical activation of the inflammasome is critical to promote caspase-1-dependent maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic cell death in response to pathogens and endogenous danger signals. Recent discoveries, however, are beginning to unveil new components of the inflammasome machinery as well as the full spectrum of inflammasome functions,...
متن کاملCorrection: Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction
V128A þ þ NA NA þ NA D155, A162 contact Q208A 6 þ NA þ þ NA H167 contact R209A 6 6 NA þ þ NA F169 contact QRY/AAA 6 6 6 NA NA H167, F169, and C-term contact D213A þ þ NA NA NA NA W154 H-bond H217A 6 6 NA NA T166 H-bond Q265A þ þ NA NA þ NA I168 contact T182A þ þ NA NA þ NA F151 contact R266A þ NA þ Y165 contact (RIN4); b-Phosphate H-bond (ADP) L109A þ þ NA NA þ NA Y165 contact (RIN4); position ...
متن کاملTarget RNA capture and cleavage by the Cmr type III-B CRISPR-Cas effector complex.
The effector complex of the Cmr/type III-B CRISPR (clustered regularly interspaced short palindromic repeat)-Cas (CRISPR-associated) system cleaves RNAs recognized by the CRISPR RNA (crRNA) of the complex and includes six protein subunits of unknown functions. Using reconstituted Pyrococcus furiosus Cmr complexes, we found that each of the six Cmr proteins plays a critical role in either crRNA ...
متن کاملType III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction
The Pseudomonas syringae type III effector protein avirulence protein B (AvrB) is delivered into plant cells, where it targets the Arabidopsis RIN4 protein (resistance to Pseudomonas maculicula protein 1 [RPM1]-interacting protein). RIN4 is a regulator of basal host defense responses. Targeting of RIN4 by AvrB is recognized by the host RPM1 nucleotide-binding leucine-rich repeat disease resista...
متن کاملA type III-B CRISPR-Cas effector complex mediating massive target DNA destruction
The CRISPR (clustered regularly interspaced short palindromic repeats) system protects archaea and bacteria by eliminating nucleic acid invaders in a crRNA-guided manner. The Sulfolobus islandicus type III-B Cmr-α system targets invading nucleic acid at both RNA and DNA levels and DNA targeting relies on the directional transcription of the protospacer in vivo. To gain further insight into the ...
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ژورنال
عنوان ژورنال: Microbe Magazine
سال: 2007
ISSN: 1558-7452,1558-7460
DOI: 10.1128/microbe.2.183.1